Robust and reliable measurements in electrochemical biosensing of molecules are crucial for personalized medicine. Electrochemical sensors based on cytochrome P450 can detect the large majority of drugs commonly used in pharmacological treatments. The same cytochrome can detect different substrates; each of them changes the electrochemical response of the enzyme in a specific manner. Our system exploits the measure of electrical potential to identify the drug type, while current measurements decode the drug concentration. Since potential and current are affected by pH and temperature, and since variations occur in the patient samples, we propose a novel design for multiplexing biosensing with pH and temperature control, which ensures more precise measurements for drugs identification and their quantification.

Multiplexing pH and Temperature in a Molecular Biosensor / Carrara, S.; Torre, M. D.; Cavallini, A.; DE VENUTO, Daniela; De Micheli, G.. - (2010), pp. 146-149. (Intervento presentato al convegno Biomedical Circuits and Systems Conference (BioCAS ‘10) tenutosi a Paphos (Cyprus) nel November 3-5, 2010) [10.1109/BIOCAS.2010.5709592].

Multiplexing pH and Temperature in a Molecular Biosensor

DE VENUTO, Daniela;
2010-01-01

Abstract

Robust and reliable measurements in electrochemical biosensing of molecules are crucial for personalized medicine. Electrochemical sensors based on cytochrome P450 can detect the large majority of drugs commonly used in pharmacological treatments. The same cytochrome can detect different substrates; each of them changes the electrochemical response of the enzyme in a specific manner. Our system exploits the measure of electrical potential to identify the drug type, while current measurements decode the drug concentration. Since potential and current are affected by pH and temperature, and since variations occur in the patient samples, we propose a novel design for multiplexing biosensing with pH and temperature control, which ensures more precise measurements for drugs identification and their quantification.
2010
Biomedical Circuits and Systems Conference (BioCAS ‘10)
978-1-4244-7270-3
Multiplexing pH and Temperature in a Molecular Biosensor / Carrara, S.; Torre, M. D.; Cavallini, A.; DE VENUTO, Daniela; De Micheli, G.. - (2010), pp. 146-149. (Intervento presentato al convegno Biomedical Circuits and Systems Conference (BioCAS ‘10) tenutosi a Paphos (Cyprus) nel November 3-5, 2010) [10.1109/BIOCAS.2010.5709592].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11589/15710
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