This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridization effect is monitored by means of a charge sensitive amplifier and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensors
Design and Characterization of Novel Read-out Systems for a Capacitive DNA Sensor / De Venuto, Daniela; Bruno, Riccò. - In: MICROELECTRONICS JOURNAL. - ISSN 0959-8324. - 37:12; Special Issue(2006), pp. 1610-1619. [10.1016/j.mejo.2006.04.020]
Design and Characterization of Novel Read-out Systems for a Capacitive DNA Sensor
De Venuto, Daniela;
2006-01-01
Abstract
This paper presents novel read-out electronic systems for a fast DNA label-less detection. The capacitive shift due to the hybridization effect is monitored by means of a charge sensitive amplifier and a differential stage. The systems provide an A/D conversion and an evaluation of the capacitive shift amount with a resolution of 11 bit. The read-out solutions demonstrate the ability to identify a 0.01% variation on the capacitive value of the sensor. The investigated techniques are suitable for monolithic systems or for a micro-fabricated array of sensorsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
