Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm x 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.
Label-free Si3N4 photonic crystal based immunosensors for diagnostic applications / Zecca, D.; Qualtieri, A.; Magno, Giovanni; Grande, Marco; Petruzzelli, Vincenzo; Prieto Simon, B.; D'Orazio, Antonella; De Vittorio, M.; Voelcker, N. H.; Stomeo, T.. - In: IEEE PHOTONICS JOURNAL. - ISSN 1943-0655. - 6:6(2014). [10.1109/JPHOT.2014.2352625]
Label-free Si3N4 photonic crystal based immunosensors for diagnostic applications
MAGNO, Giovanni;GRANDE, Marco;PETRUZZELLI, Vincenzo;D'ORAZIO, Antonella;
2014-01-01
Abstract
Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm x 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.File | Dimensione | Formato | |
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