A mild and sustainable synthesis of 2,2-disubstituted oxetanes has been achieved through the use of a fow microreactor system. By controlling the residence time a highly unstable intermediate such as 2-phenyloxetan-2-yl lithium can be generated and trapped with various electrophiles afording in moderate to good yields 2-substituted-2-phenyloxetanes at higher temperatures with respect to macrobatch-mode where -78 °C is required.
Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium / Degennaro, Leonardo; Nagaki, Aiichiro; Moriwaki, Yuya; Romanazzi, Giuseppe; Dell'Anna, Maria Michela; Yoshida, Jun-Ichi; Luisi, Renzo. - In: OPEN CHEMISTRY. - ISSN 2391-5420. - ELETTRONICO. - 14:1(2016), pp. 377-382. [10.1515/chem-2016-0041]
Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium
Romanazzi, Giuseppe;Dell'Anna, Maria Michela;
2016-01-01
Abstract
A mild and sustainable synthesis of 2,2-disubstituted oxetanes has been achieved through the use of a fow microreactor system. By controlling the residence time a highly unstable intermediate such as 2-phenyloxetan-2-yl lithium can be generated and trapped with various electrophiles afording in moderate to good yields 2-substituted-2-phenyloxetanes at higher temperatures with respect to macrobatch-mode where -78 °C is required.| File | Dimensione | Formato | |
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Open Chem., 2016 14 377–382.pdf
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