One of the most challenging problems of the ancient architectural heritage is its protection from fire risk. The “Italian Risk assessment map of the cultural heritage” (Carta del Rischio [1]), is a GIS-based platform developed by the Italian Central Institute for Restoration (ISCR) to assess the exposure and the vulnerability to static-structural, environmental, anthropogenic and seismic risk of the historical and cultural heritage. The paper marks a new phase of development of the Risk Map Information System aiming at integrating the vulnerability estimation of the historical buildings with a new method derived from the Fire Risk Index Method for Multi-storey Apartment Buildings (FRIM-MAB). The new index-based method has been tested in a full scale case-study in comparison with both the Italian prescriptive assessment and the performance-based fire protection approach. Results show the capability of the approach, its reliability and user friendliness