Constitutive behavior of living cells is in deep relationship with their biological properties. For that reason gathering the most detailed information on cell mechanical behavior as it is feasible becomes extremely useful in assessing therapeutic protocols. However, investigation of elastic properties of living cells is a fairly complicated process that requires the use of advanced sensing devices. For example, Atomic Force Microscopy (AFM) is a research tool largely used by biomedical engineers and biophysicists for studying cell mechanics. Experimental data can be given in input to finite element models to predict cell behavior and to simulate the tissue response to biophysical, chemical or pharmacological stimuli of different nature. The paper analyzes different aspects involved in the numerical simulation of AFM measurements on living cells focusing in particular on the effect of constitutive behavior.
Elastic properties of living cells / Frassanito, Maria Cristina; Lamberti, L; Pappalettere, C (CONFERENCE PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL MECHANICS SERIES). - In: Experimental and Applied Mechanics. Vol. 6: proceedings of the 2010 Annual Conference on Experimental and Applied Mechanics, SEM 2010 / [a cura di] Tom Proulx. - STAMPA. - New York, NY : Springer, 2011. - ISBN 978-1-4419-9497-4. - pp. 17-22 [10.1007/978-1-4419-9792-0_3]
Elastic properties of living cells
Frassanito, Maria Cristina;Lamberti L;Pappalettere C
2011-01-01
Abstract
Constitutive behavior of living cells is in deep relationship with their biological properties. For that reason gathering the most detailed information on cell mechanical behavior as it is feasible becomes extremely useful in assessing therapeutic protocols. However, investigation of elastic properties of living cells is a fairly complicated process that requires the use of advanced sensing devices. For example, Atomic Force Microscopy (AFM) is a research tool largely used by biomedical engineers and biophysicists for studying cell mechanics. Experimental data can be given in input to finite element models to predict cell behavior and to simulate the tissue response to biophysical, chemical or pharmacological stimuli of different nature. The paper analyzes different aspects involved in the numerical simulation of AFM measurements on living cells focusing in particular on the effect of constitutive behavior.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
