The usual assumption made in mechanical characterization of soft biotissues with Atomic Force Microscopy (AFM) is that the specimen behaves as a purely elastic material. However, there is a limit indentation rate below which viscous effects can be neglected. A parametric study including about 200 FEM analyses shows that in the case of immature porcine zona pellucida (ZP) samples viscous effects become more significant for sharp tips. A linear relationship between the limit indentation rate and the geometry of the AFM probe is derived for the porcine ZP samples analyzed in this study

A deeper look into immature porcine zona pellucida visco-hyperelasticity

BOCCACCIO, Antonio;LAMBERTI, Luciano;PAPPALETTERE, Carmine
2016-01-01

Abstract

The usual assumption made in mechanical characterization of soft biotissues with Atomic Force Microscopy (AFM) is that the specimen behaves as a purely elastic material. However, there is a limit indentation rate below which viscous effects can be neglected. A parametric study including about 200 FEM analyses shows that in the case of immature porcine zona pellucida (ZP) samples viscous effects become more significant for sharp tips. A linear relationship between the limit indentation rate and the geometry of the AFM probe is derived for the porcine ZP samples analyzed in this study
2016
Annual Conference and Exposition of the Society-for-Experimental-Mechanics on Experimental and Applied Mechanics, SEM 2015
978-3-319-21455-9
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11589/18456
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