C-Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection-deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to the arsenic atom as dithioarsenical (AsIII), showed promising antiproliferative activity on a cell line of neuroblastoma (SK-N-BE). C-Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized. The C-glucoside conjugated to the phenyldithioarsolan group, showed promising antiproliferative activity on human neuroblastoma cells (SK-N-BE).
Arsenical C-Glucoside Derivatives with Promising Antitumor Activity / D'Orazio, Giuseppe; Parisi, Gelsomina; Policano, Claudia; Mechelli, Rosella; Codacci Pisanelli, Giovanni; Pitaro, Michele; Ristori, Giovanni; Salvetti, Marco; Nicotra, Francesco; La Ferla, Barbara. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - 2015:21(2015), pp. 4620-4623. [10.1002/ejoc.201500529]
Arsenical C-Glucoside Derivatives with Promising Antitumor Activity
Giuseppe D'Orazio;
2015-01-01
Abstract
C-Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection-deprotection steps. While compound 1, bearing an AsV atom, did not show any significant biological activity, compound 2, in which the glucose moiety is linked to the arsenic atom as dithioarsenical (AsIII), showed promising antiproliferative activity on a cell line of neuroblastoma (SK-N-BE). C-Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized. The C-glucoside conjugated to the phenyldithioarsolan group, showed promising antiproliferative activity on human neuroblastoma cells (SK-N-BE).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
