By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl-or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included. © 2014 by the authors.
Synthesis of functionalized arylaziridines as potential antimicrobial agents / Giovine, Arianna; Muraglia, Marilena; Florio, Marco Antonio; Rosato, Antonio; Corbo, Filomena; Franchini, Carlo; Musio, Biagia; Degennaro, Leonardo; Luisi, Renzo. - In: MOLECULES. - ISSN 1420-3049. - ELETTRONICO. - 19:8(2014), pp. 11505-11519. [10.3390/molecules190811505]
Synthesis of functionalized arylaziridines as potential antimicrobial agents
Musio, Biagia;
2014-01-01
Abstract
By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl-or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included. © 2014 by the authors.| File | Dimensione | Formato | |
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