(Chemical Equation Presented) The ortho lithiation-trapping sequence of phenylaziridines is described. This methodology, which counts on the ability of the aziridino group to act as a directed metalation group (DMG), provides an easy access to functionalized arylaziridines as well as to phthalans and phthalides. The importance of the aziridine N-substituent in this DoM reaction is stressed as well. © 2005 American Chemical Society.
Directed ortho lithiation of N-alkylphenylaziridines / Capriati, V.; Florio, S.; Luisi, R.; Musio, B.. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 7:17(2005), pp. 3749-3752. [10.1021/ol051412l]
Directed ortho lithiation of N-alkylphenylaziridines
Musio B.
2005-01-01
Abstract
(Chemical Equation Presented) The ortho lithiation-trapping sequence of phenylaziridines is described. This methodology, which counts on the ability of the aziridino group to act as a directed metalation group (DMG), provides an easy access to functionalized arylaziridines as well as to phthalans and phthalides. The importance of the aziridine N-substituent in this DoM reaction is stressed as well. © 2005 American Chemical Society.File in questo prodotto:
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