Flow chemistry: A flow-microreactor-mediated synthesis of 1,2,3,4-tetrahydroisoquinolines (THIQs) is reported (see scheme). Starting from a laterally lithiated aziridine, a tetrahydroisoquinoline lithiated at C4 was generated by thermally induced isomerization. Because the reaction temperature is a crucial parameter, the exquisite thermal control possible in a flow-microreactor system allowed for fast, efficient, and highly reproducible synthesis of functionalized aziridines or THIQs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Synthesis of 1,2,3,4-tetrahydroisoquinolines by microreactor-mediated thermal isomerization of laterally lithiated arylaziridines / Giovine, A.; Musio, B.; Degennaro, L.; Falcicchio, A.; Nagaki, A.; Yoshida, J. -I.; Luisi, R.. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 19:6(2013), pp. 1872-1876. [10.1002/chem.201203533]

Synthesis of 1,2,3,4-tetrahydroisoquinolines by microreactor-mediated thermal isomerization of laterally lithiated arylaziridines

Musio B.;
2013-01-01

Abstract

Flow chemistry: A flow-microreactor-mediated synthesis of 1,2,3,4-tetrahydroisoquinolines (THIQs) is reported (see scheme). Starting from a laterally lithiated aziridine, a tetrahydroisoquinoline lithiated at C4 was generated by thermally induced isomerization. Because the reaction temperature is a crucial parameter, the exquisite thermal control possible in a flow-microreactor system allowed for fast, efficient, and highly reproducible synthesis of functionalized aziridines or THIQs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
2013
Synthesis of 1,2,3,4-tetrahydroisoquinolines by microreactor-mediated thermal isomerization of laterally lithiated arylaziridines / Giovine, A.; Musio, B.; Degennaro, L.; Falcicchio, A.; Nagaki, A.; Yoshida, J. -I.; Luisi, R.. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 19:6(2013), pp. 1872-1876. [10.1002/chem.201203533]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11589/223788
Citazioni
  • Scopus 45
  • ???jsp.display-item.citation.isi??? 44
social impact