Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non-linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye-based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.
Electroporation Modelling of Irregularly Nucleated Cell with Perinuclear Space / Mescia, Luciano; Bia, Pietro; Maria Lamacchia, Claudio; Alessandro Chiapperino, Michele; Miani, Alessandro. - ELETTRONICO. - (2021). (Intervento presentato al convegno IEEE MTT-S International Microwave Biomedical Conference, IMBioC 2020 tenutosi a Toulouse, France nel December 14-17, 2020) [10.1109/IMBIoC47321.2020.9385010].
Electroporation Modelling of Irregularly Nucleated Cell with Perinuclear Space
Luciano Mescia;
2021-01-01
Abstract
Electroporation technique is based on the perturbation of the cell membrane through the application of high-voltage electric pulses of short duration. In this paper, a non-linear dispersive model of the electroporation process in irregularly nucleated shaped cells is presented. In particular, the nuclear envelope was modeled as two lipid membranes separated by a perinuclear space. The dispersive properties of biological media was taken into account using a Debye-based relationship. The Multiphysics model solves simultaneously the Maxwell equations, the Smoluchowski equation, describing the creation and closure of pores, and the equations describing the temporal evolution of pore radius.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
