Lab-on-chips (LoCs) are microsystems capable of manipulating small amounts of fluids in microfluidic channels. They have a huge application potential, from basic science to chemical synthesis and point-of-care medical analysis. Polymers are rapidly emerging as the substrate of choice for LoC production, thanks to a lowmaterial cost and ease of processing. Two breakthroughs that could promote LoC diffusion are amicrofabrication technology with cost-effective and rapid prototyping capabilities and also an integrated on-chip optical detection system. This chapter proposes the use of femtosecond laser micromachining combined with microinjection moulding as a novel highly-flexible microfabrication platform for polymeric LoCs with integrated optical detection, for the realization of low-cost and truly portable biophotonic microsystems. We demonstrate a LoC for the relevant application of non-invasive and contactless mechanical phenotyping of single cancer cells.
Plastic lab-on-chip for the optical manipulation of single cells / Vazquez, R. M.; Trotta, G.; Volpe, A.; Paturzo, M.; Modica, F.; Bianco, V.; Coppola, S.; Ancona, A.; Ferraro, P.; Fassi, I.; Osellame, R.. - (2019), pp. 339-363. [10.1007/978-3-319-94358-9_16]
Plastic lab-on-chip for the optical manipulation of single cells
Volpe A.Membro del Collaboration Group
;Bianco V.;
2019-01-01
Abstract
Lab-on-chips (LoCs) are microsystems capable of manipulating small amounts of fluids in microfluidic channels. They have a huge application potential, from basic science to chemical synthesis and point-of-care medical analysis. Polymers are rapidly emerging as the substrate of choice for LoC production, thanks to a lowmaterial cost and ease of processing. Two breakthroughs that could promote LoC diffusion are amicrofabrication technology with cost-effective and rapid prototyping capabilities and also an integrated on-chip optical detection system. This chapter proposes the use of femtosecond laser micromachining combined with microinjection moulding as a novel highly-flexible microfabrication platform for polymeric LoCs with integrated optical detection, for the realization of low-cost and truly portable biophotonic microsystems. We demonstrate a LoC for the relevant application of non-invasive and contactless mechanical phenotyping of single cancer cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
