In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions. The greenness of the process is harnessed by the use of flow technology for handling a biphasic segmented flow and the use of an inline liquid-liquid separator allowing the recovery of both the eco-friendly organic solvent (CPME) and the reusable acidic aqueous phase.
Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines / Andresini, M.; Colella, M.; Dibenedetto, R. S.; Graziano, E.; Romanazzi, G.; Aramini, A.; Degennaro, L.; Luisi, R.. - In: REACTION CHEMISTRY & ENGINEERING. - ISSN 2058-9883. - 8:12(2023), pp. -3209. [10.1039/d3re00342f]
Sustainable continuous flow synthesis of β-aminocarbonyls via acid-catalyzed hydration of N-Boc-2-azetines
Romanazzi G.;
2023-01-01
Abstract
In this work we report a waste-minimized continuous flow process for the synthesis of β-aminocarbonyls through hydration of N-Boc-2-azetines promoted under acid-catalysed conditions. The greenness of the process is harnessed by the use of flow technology for handling a biphasic segmented flow and the use of an inline liquid-liquid separator allowing the recovery of both the eco-friendly organic solvent (CPME) and the reusable acidic aqueous phase.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
