The pioneering design of a wearable miniaturized and flexible potentiometric chloride activity sensing platform to provide real-time diagnosis and monitoring of Cystic Fibrosis (CF) is here presented. To ensure wearable and comfortable functionality, a flexible support has been employed for both the electrodes monitoring the changes in ion concentration in the sample solution and the smart readout electronics. The proposed electronic system embeds a microcontroller, enabling potential analysis of the acquired data together with the patient history and an RF module. It ensures wireless transmission of measurements and diagnosis to a remote healthcare center. Experimental results on proposed device showed that the developed bendable electrodes have Nernstian sensitivity (about 57 mV/dec of chloride concentration) within the 5 mmol/l–75 mmol/l range, which is relevant for CF screening. The proposed system is capable of detecting chloride concentrations with error margin spanning from ±0.16 mM (around 5 mmol/l) to ±2.94 mM (in the worst-case at 100 mmol/l) using a 50 µl of sweat sample. The presence of a μController enables the AI data analysis, making possible the diagnosis and the follow-up monitoring of patients under pharmaceutical treatments. The results closely match the precision of specialized medical equipment, suggesting the potential utility of this device in the fight against CF.
Chloride Activity Sensing in Sweat for Cystic Fibrosis Diagnosis by Biocompatible Flexible Tag / De Venuto, Daniela; De Venuto, Domenica; Mezzina, G.; Mascellaro, Grazia; Torsi, Luisa. - 1113:(2024), pp. 137-149. (Intervento presentato al convegno 54th Annual Meeting of the Italian Electronics Society, SIE 2023 tenutosi a ita nel 2023) [10.1007/978-3-031-48711-8_16].
Chloride Activity Sensing in Sweat for Cystic Fibrosis Diagnosis by Biocompatible Flexible Tag
De Venuto Daniela
;Mascellaro Grazia;
2024-01-01
Abstract
The pioneering design of a wearable miniaturized and flexible potentiometric chloride activity sensing platform to provide real-time diagnosis and monitoring of Cystic Fibrosis (CF) is here presented. To ensure wearable and comfortable functionality, a flexible support has been employed for both the electrodes monitoring the changes in ion concentration in the sample solution and the smart readout electronics. The proposed electronic system embeds a microcontroller, enabling potential analysis of the acquired data together with the patient history and an RF module. It ensures wireless transmission of measurements and diagnosis to a remote healthcare center. Experimental results on proposed device showed that the developed bendable electrodes have Nernstian sensitivity (about 57 mV/dec of chloride concentration) within the 5 mmol/l–75 mmol/l range, which is relevant for CF screening. The proposed system is capable of detecting chloride concentrations with error margin spanning from ±0.16 mM (around 5 mmol/l) to ±2.94 mM (in the worst-case at 100 mmol/l) using a 50 µl of sweat sample. The presence of a μController enables the AI data analysis, making possible the diagnosis and the follow-up monitoring of patients under pharmaceutical treatments. The results closely match the precision of specialized medical equipment, suggesting the potential utility of this device in the fight against CF.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
