Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm x 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.
|Titolo:||Label-free Si3N4 photonic crystal based immunosensors for diagnostic applications|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1109/JPHOT.2014.2352625|
|Appare nelle tipologie:||1.1 Articolo in rivista|