Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm x 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.

Label-free Si3N4 photonic crystal based immunosensors for diagnostic applications

MAGNO, Giovanni;GRANDE, Marco;PETRUZZELLI, Vincenzo;D'ORAZIO, Antonella;
2014-01-01

Abstract

Immunosensors are devices that exploit immobilized antibodies to promote the binding of specific analytes related to diseases of medical importance, such as cancer or cardiac dysfunctions. Label-free immunosensors have an important role, due to their simplicity and fast read-out. Here, the proof of concept for an immunosensor based on a 2-D photonic crystal silicon nitride membrane is presented. The device has been fabricated by means of a well-tuned nanofabrication protocol, achieving a high-quality photonic pattern on a large-area membrane (1 mm x 1 mm), and it has been tested for the detection of interleukin-6, getting protein detection at pg/mL concentrations.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11589/55844
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