Mechanical hemolysis is a major concern in the design of cardiovascular devices, such as prosthetic heart valves and ventricular assist devices. The primary cause of mechanical hemolysis is the impact of the device on the local blood ﬂow, which exposes blood elements to non-physiologic conditions. The majority of existing hemolysis models correlate red blood cell (RBC) damage to the imposed ﬂuid shear stress and exposure time. Only recently more realistic, strain-based models have been proposed, where the RBC’s response to the imposed hydrodynamic loading is accounted for. In the present work we extend strain-based models by introducing a high-ﬁdelity representation of RBCs, which is based on existing coarse-grained particle dynamics approach. We report a series of numerical experiments in simple shear ﬂows of increasing complexity, to illuminate the basic differences between existing models and establish their accuracy in comparison to the high-ﬁdelity RBC approach. We also consider a practical conﬁguration, where the ﬂow through an artiﬁcial heart valve is computed. Our results shed light on the strengths and weaknesses of each approach and identify the key gaps that should be addressed in the development of new models.
|Titolo:||A Strain-Based Model for Mechanical Hemolysis Based on a Coarse-Grained Red Blood Cell Model|
|Data di pubblicazione:||2015|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10439-015-1273-z|
|Appare nelle tipologie:||1.1 Articolo in rivista|