Microreactor-mediated organocatalysed Michael reactions have been developed. By using a soluble proline-derived catalyst, Michael-type reactions, leading to gamma-nitroketones, have been optimized in homogeneous and continuous-flow conditions. As proof of principle, an integrated microfluidic system able to perform domino processes useful in the preparation of bicyclo[4.4.0]decanes with six contiguous stereogenic centres has been set up.
Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions / Carroccia, Laura; Musio, Biagia; Degennaro, Leonardo; Romanazzi, Giuseppe; Luisi, Renzo. - In: JOURNAL OF FLOW CHEMISTRY. - ISSN 2062-249X. - 3:2(2013), pp. 29-33. [10.1556/JFC-D-13-00003]
Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions
Biagia Musio;Giuseppe Romanazzi;
2013-01-01
Abstract
Microreactor-mediated organocatalysed Michael reactions have been developed. By using a soluble proline-derived catalyst, Michael-type reactions, leading to gamma-nitroketones, have been optimized in homogeneous and continuous-flow conditions. As proof of principle, an integrated microfluidic system able to perform domino processes useful in the preparation of bicyclo[4.4.0]decanes with six contiguous stereogenic centres has been set up.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
