Microreactor-mediated organocatalysed Michael reactions have been developed. By using a soluble proline-derived catalyst, Michael-type reactions, leading to gamma-nitroketones, have been optimized in homogeneous and continuous-flow conditions. As proof of principle, an integrated microfluidic system able to perform domino processes useful in the preparation of bicyclo[4.4.0]decanes with six contiguous stereogenic centres has been set up.
|Titolo:||Microreactor-Mediated Organocatalysis: Towards the Development of Sustainable Domino Reactions|
|Data di pubblicazione:||2013|
|Digital Object Identifier (DOI):||10.1556/JFC-D-13-00003|
|Appare nelle tipologie:||1.1 Articolo in rivista|