The regioselective lithiation-functionalization of 2-arylazetidines has been explored. The nature of the N-substituent is mainly responsible for a regioselectivity switch. ortho-Lithiation occurred, using hexyllithium as a greener base, in N-alkylazetidines, while α-benzylic lithiation has been observed with N-Boc azetidines.
|Titolo:||Regioselective functionalization of 2-arylazetidines: evaluating the ortho-directing ability of the azetidinyl ring and the α-directing ability of the N-substituent|
|Data di pubblicazione:||2014|
|Digital Object Identifier (DOI):||10.1039/c3cc48555b|
|Appare nelle tipologie:||1.1 Articolo in rivista|