A multi-analyte biosensing platform for the selective label-free detection of protein biomarkers has been designed through a three-dimensional model based on the finite element method. The sensing element of the platform is a planar plasmonic nanocavity, consisting of a one-dimensional periodic structure (Bragg grating) in gold, with a defect, placed on the buried oxide of a silicon-on-insulator substrate. The footprint of this sensing element, which has a good chemical stability, is only 1.57 μm 2 . The sensor has a detection limit of 128 pg/mm 2 and a surface sensitivity of 1.8 nm/nm.
Design of a label-free multiplexed biosensing platform based on an ultracompact plasmonic resonant cavity / Dell’Olio, Francesco; Conteduca, Donato; De Palo, Maripina; Sasanelli, Nicola; Ciminelli, Caterina (LECTURE NOTES IN ELECTRICAL ENGINEERING). - In: Sensors : proceedings of the Fourth National Conference on Sensors, February 21-23, 2018, Catania, Italy / [a cura di] Bruno Andò; Francesco Baldini; Corrado Di Natale; Vittorio Ferrari; Vincenzo Marletta; Giovanna Marrazza; Valeria Militello; Giorgia Miolo; Marco Rossi; Lorenzo Scalise; Pietro Siciliano. - STAMPA. - Cham, CH : Springer, 2019. - ISBN 978-3-030-04323-0. - pp. 263-267 [10.1007/978-3-030-04324-7_34]
Design of a label-free multiplexed biosensing platform based on an ultracompact plasmonic resonant cavity
Dell’Olio, Francesco;Conteduca, Donato;Sasanelli, Nicola;Ciminelli, Caterina
2019-01-01
Abstract
A multi-analyte biosensing platform for the selective label-free detection of protein biomarkers has been designed through a three-dimensional model based on the finite element method. The sensing element of the platform is a planar plasmonic nanocavity, consisting of a one-dimensional periodic structure (Bragg grating) in gold, with a defect, placed on the buried oxide of a silicon-on-insulator substrate. The footprint of this sensing element, which has a good chemical stability, is only 1.57 μm 2 . The sensor has a detection limit of 128 pg/mm 2 and a surface sensitivity of 1.8 nm/nm.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
