Ocular Biometric Measurements to Diagnose Neurological Disorders due to Wilson Disease

Wilson disease is a pathology due to a gene mutation causing malfunction in the copper excretion from the organism. Consequently, copper accumulation in the body gives rise to oxidative processes. So, this rare disease is responsible of several disorders affecting tissues and organs. Neurological disorders are common consequence of copper accumulation in the brain. About 95% of individuals with neurological/psychiatric disorders show a visible symptom in their eyes known as Kayser-Fleischer ring. It is a golden-brown, sometimes orange or greyish, ring due to copper deposit in the cornea. In medical screening, it is considered a diagnostic sign of Wilson disease more than ever in individuals with neurological problems. The authors propose an innovative technique based on ocular biometric measurements to diagnose the pathology and the origin of neurological disorder. An image processing algorithm detects the Kayser-Fleischer ring in eye cornea by segmentation. Subsequently, biometric measurements provide further information on the severity level of pathology. The aim is to provide a non-invasive diagnostic technique improving the accuracy of the current methods used in practice and reducing possible interpretation errors.