New ultrasensitive resonant photonic platform for label-free biosensing

A multi-analyte biosensing platform with ultra-high resolution (= 0.2 ng/mL),-which is appropriate for the detection in the human serum of a wide range of biomarkers, e.g. those allowing the lung cancer early diagnosis, has been designed. The platform is based on a new configuration of planar ring resonator. The very strong light-matter interaction enabled by the micro-cavity allows a record limit-of-detection of 0.06 pg/mm2, five times better than the state-of-the-art. The device with footprint = 2,200 μm2 for each ring, due to its features, has the potential to be integrated in lab-onchip microsystems for large-scale screenings of people with high risk of developing cancer.